I-Alkyl Polyglycosides Emikhiqizweni Yokunakekela Umuntu

Kule minyaka eyishumi edlule, ukuthuthukiswa kwezinto ezingavuthiwe zemikhiqizo yokunakekelwa komuntu siqu kuthuthuke ezindaweni ezintathu eziyinhloko:

(1) ubumnene nokunakekela isikhumba

(2) amazinga ekhwalithi ephezulu ngokunciphisa imikhiqizo etholakalayo kanye nokulandela ukungcola

(3) ukuhambisana kwemvelo.

Imithethonqubo esemthethweni nezidingo zabathengi ziya ngokuya zikhuthaza intuthuko elandela imigomo yenqubo nokusimama komkhiqizo. Isici esisodwa salesi simiso ukukhiqizwa kwe-alkyl glycosides emafutheni emifino nama-carbohydrate asuka emthonjeni ovuselelekayo. Ukuthuthukiswa kobuchwepheshe bezentengiselwano kudinga izinga eliphezulu lokulawula izinto ezingavuthiwe, ukusabela kanye nezimo zokucubungula ukuze kuhlangatshezwane nezidingo zekhwalithi yempahla yesimanje yezimonyo kanye nokuzikhiqiza ngenani elifanele. Emkhakheni wezimonyo, i-alkyl glucoside iwuhlobo olusha lwe-surfactant enezici ezivamile ezingezona i-ionic ne-anionic. Kuze kube manje, ingxenye enkulu yemikhiqizo yezentengiselwano yizihlanzi ezimelelwe i-C8-14 alkyl glycosides, ebonakala ngezimpawu zokunakekelwa kwesikhumba nezinwele. I-C12-14 i-alkyl polyglycoside isebenza njenge-emulsifier ekwenziweni okuthile futhi ikakhulukazi kuma-microemulsions kanye nokutadisha ukusebenza kwe-C16-18 alkyl polyglycoside njengesisekelo esizikhandlayo se-o/w esihlanganiswe notshwala obunamafutha.

Ngokwakhiwa kokuhlanza umzimba, isisebenzi esisha sesimanje kufanele sihambisane kahle nesikhumba kanye nolwelwesi lwamafinyila. Ukuhlolwa kwesikhumba kanye ne-toxicological kuyadingeka ukuze kuhlolwe ubungozi be-surfactant entsha kanye nomklamo okubaluleke kakhulu ukuhlonza okungase kube khona ukukhuthazwa kwamaseli aphilayo kungqimba lwe-epidermal basal. Esikhathini esedlule, lokhu kube isisekelo sezimangalo zobumnene be-surfactant. Ngesikhathi esifanayo, incazelo yobumnene ishintshe kakhulu.Namuhla, ubumnene buqondwa njengokuhambisana okuphelele kwama-surfactants ne-physiology kanye nomsebenzi wesikhumba somuntu.

Ngezindlela ezihlukahlukene ze-dermatological kanye ne-biophysical, imiphumela ye-physiological ye-surfactants esikhumbeni yafundwa, kusukela ebusweni besikhumba futhi iqhubekela kungqimba olujulile lwamaseli e-basal ngokusebenzisa i-stratum corneum kanye nomsebenzi wayo wokuvinjelwa. , njengokuzwela kwesikhumba, zirekhodwa ngolimi lokuthinta kanye nesipiliyoni.

I-Alkyl polyglycosides enamaketanga e-alkyl e-C8 kuya ku-C16 ayingxenye yeqembu lama-surfactants athambile kakhulu okwakhiwa kokuhlanza umzimba. Ocwaningweni oluningiliziwe, ukuhambisana kwe-alkyl polyglycosides kwachazwa njengomsebenzi weketango le-alkyl elimsulwa kanye nezinga le-polymerization.Esivivinyweni esilungisiwe se-Duhring Chamber, i-C12 alkyl polyglycoside ibonisa ubuningi obuhlobene phakathi kwebanga lokucasuka okuncane kuyilapho i-C8, I-C10 ne-C14, i-C16 i-alkyl polyglycoside ikhiqiza amaphuzu aphansi okucasuka. Lokhu kuhambisana nokubhekwa namanye amakilasi ama-surfactants. Ngaphezu kwalokho, ukucasuka kuncipha kancane ngezinga elikhulayo le-polymerization (kusuka ku-DP= 1.2 kuya ku-DP= 1.65).

Imikhiqizo ye-APG enobude obuxubile be-alkyl chain inokuhambisana okuhle kakhulu sekukonke nengxenye ephezulu ye-alkyl glycosides ende (C12-14).Iqhathaniswe nokwengezwa kwe-alkyl ether sulphates emnene kakhulu, i-amphoteric glycine noma i-amphoteric acetate, kanye nephrotheni ethambile kakhulu. -ama-fatty acids ku-collagen noma ezintweni zikakolweni ze-proteolytic.

Okutholwe ngesikhumba ekuhlolweni kokugezwa kwengalo kubonisa izinga elifanayo njengase-Duhring Chamber Test lapho kuphenywa khona amasistimu axubile e-alkyl ether sulfate ne-alkyl polyglycosides noma ama-amphoteric co-surfactants. Kodwa-ke, ukuhlolwa kwe-arm flex wash kuvumela ukuhlukaniswa okungcono kwemiphumela. Ukwakheka kwe-erythema kanye ne-squamation kungancishiswa ngo-20-30 D/o uma cishe u-25 °10 we-SLES kushintshaniswa i-alkyl polyglycoside ekhombisa ukuncipha cishe ngo-60%. Ekwakheni okuhlelekile kokwakheka, okuhle kungafinyelelwa ngokungezwa kokuphuma kokuphuma kwamaprotheni noma ama-amphoteric.